Biography
Recently I left working at MTL-department and transferred to the college of Health and Medical Technologies as an Associate Dean for Scientific and Graduate Affaires .I did my PhD at Newcastle University (Prof. Loranne Agius' Lab.) on the mechanism of action of metformin in hepatocytes (HCED scholarship). I am interested in diabetes and glucose metabolism in the liver, adipose tissue. anti-hyperglycemic treatment (metformin) and its role in regulation of glucose and lipid metabolism in T2D patients, focusing on Adiponectin, Fibroblast Growth Factor-21 and its receptor (FGFR1c)/co-receptor (KLB), and the cleavage enzyme Fibroblast activation protein-alpha ORCID ID: 0000-0002-0328-3486; Scopus Author ID: 57193900786; Research ID: J-1256-2019. Pubmed: alshawi_ahmed@orcidRsearch Interests
- I am interested in diabetes and glucose metabolism in the liver, adipose tissue. anti-hyperglycemic treatment (metformin) and its role in regulation of glucose and lipid metabolism in T2D patients, focusing on Adiponectin, Fibroblast Growth Factor-21 and its receptor (FGFR1c)/co-receptor (KLB), and the cleavage enzyme Fibroblast activation protein-alpha
Qualifications
- PhD in Clinical biochemistry, Newcastle University, Newcastle Upon Tyne and Wear. UK 2019
- MSc Medical Lab. 2009, College of Health and Medical Technology, Middle Technical University. Baghdad, Iraq
- BSc Medical Lab. Technologies. Baghdad, Iraq
Scientific Supervision
- Now, I have one MSc student/ working on Macrophage scavenger receptor-1, ATP Binding Cassette Subfamily 1 with T2D, Pre-diabetes
- I had a MSc student/College of Health and Medical Technologies 2024-2025
She worked on the role of metformin on FGF-21, its receptor/co-receptor, and FAP-alpha in T2D patients
- I had a MSc student during 2023-2024, she works on the effect of metformin high-molecular weight-adiponectin, AMPK, and FGF-21 in T2D
Scientific Research
- Compromised chronic efficacy of a glucokinase activator AZD1656 in mouse models for common human GCKR variants
- High-Molecular weight Adiponectin, and TyG-BMI, are better predictive markers than TyG index and HbA1c to predict pre-diabetes in overweight adults
- COVID-19 infection causes insulin-resistance between hospitalised patients in Najaf governorate COVID-19 Infection Causes Insulin-Resistance between Hospitalised Patients in Najaf Governorate
- Chronic Glucokinase Activator treatment activates liver Carbohydrate Response Element binding protein and improves hepatocyte ATP homeostasis during substrate challenge
- TG/HDL, Non-HDL, and TyG index as predictive parameters for CVDs in uncontrolled diabetic patients better than LDL-C and LDL/HDL ratio
- Increases Aspartate Aminotransferase Activity Negatively Correlated with D-Dimer in Early Diagnosed SARS-CoV-2 Patients
- Chronic Glucokinase Activator treatment activates liver Carbohydrate Response Element binding protein and improves hepatocyte ATP homeostasis during substrate challenge
- Metformin lowers glucose 6-phosphate in hepatocytes by activation of glycolysis downstream of glucose phosphorylation
- Low metformin causes a more oxidized mitochondrial NADH/NAD redox state in hepatocytes and inhibits gluconeogenesis by a redox-independent mechanism
- Opposite effects of a glucokinase activator and metformin on glucose-regulated gene expression in hepatocytes: Converse mechanisms of metformin and a GKA on liver gene regulation
