Biography
I am currently working at MTL-department as a head of department/ Kufa institute/ Al-Furat Al-Awsat Technical University. I did my PhD at Newcastle University (Prof. Loranne Agius' Lab.) on the mechanism of action of metformin in hepatocytes (HCED scholarship). I am interested in diabetes and glucose metabolism in the liver, adipose tissue. anti-hyperglycemic treatment (metformin) and its role in regulation of glucose and lipid metabolism in T2D patients, focusing on Adiponectin, Fibroblast Growth Factor-21 and its receptor (FGFR1c)/co-receptor (KLB), and the cleavage enzyme Fibroblast activation protein-alpha ORCID ID: 0000-0002-0328-3486; Scopus Author ID: 57193900786; Research ID: J-1256-2019. Pubmed: alshawi_ahmed@orcid
Rsearch Interests
- I am interested in diabetes and glucose metabolism in the liver, adipose tissue. anti-hyperglycemic treatment (metformin) and its role in regulation of glucose and lipid metabolism in T2D patients, focusing on Adiponectin, Fibroblast Growth Factor-21 and its receptor (FGFR1c)/co-receptor (KLB), and the cleavage enzyme Fibroblast activation protein-alpha
Qualifications
- PhD in Clinical biochemistry, Newcastle University, Newcastle Upon Tyne and Wear. UK 2019
- MSc Medical Lab. 2009, College of Health and Medical Technology, Middle Technical University. Baghdad, Iraq
- BSc Medical Lab. Technologies. Baghdad, Iraq
Scientific Supervision
- Currently, I am a supervisor of one MSc student/College of Health and Medical Technologies 2024-2025
She is working on the role of metformin on FGF-21, its receptor/co-receptor, and FAP-alpha in T2D patients
- I had a MSc student during 2023-2024, she works on the effect of metformin high-molecular weight-adiponectin, AMPK, and FGF-21 in T2D
Scientific Research
- Compromised chronic efficacy of a glucokinase activator AZD1656 in mouse models for common human GCKR variants
- High-Molecular weight Adiponectin, and TyG-BMI, are better predictive markers than TyG index and HbA1c to predict pre-diabetes in overweight adults
- COVID-19 infection causes insulin-resistance between hospitalised patients in Najaf governorate COVID-19 Infection Causes Insulin-Resistance between Hospitalised Patients in Najaf Governorate
- Chronic Glucokinase Activator treatment activates liver Carbohydrate Response Element binding protein and improves hepatocyte ATP homeostasis during substrate challenge
- TG/HDL, Non-HDL, and TyG index as predictive parameters for CVDs in uncontrolled diabetic patients better than LDL-C and LDL/HDL ratio
- Increases Aspartate Aminotransferase Activity Negatively Correlated with D-Dimer in Early Diagnosed SARS-CoV-2 Patients
- Chronic Glucokinase Activator treatment activates liver Carbohydrate Response Element binding protein and improves hepatocyte ATP homeostasis during substrate challenge
- Metformin lowers glucose 6-phosphate in hepatocytes by activation of glycolysis downstream of glucose phosphorylation
- Low metformin causes a more oxidized mitochondrial NADH/NAD redox state in hepatocytes and inhibits gluconeogenesis by a redox-independent mechanism
- Opposite effects of a glucokinase activator and metformin on glucose-regulated gene expression in hepatocytes: Converse mechanisms of metformin and a GKA on liver gene regulation
