ملخص البحث :

A new series of chiral thiourea derivatives (5a–5c) and thiourea containing benzimidazolemoieties (9b–9e) were synthesized from different amino acids (L-valine, L-isoleucine, Lmethionine,L-phenylalanine, and D-phenylglycine). The compounds were characterized andtested against the two most studied members of the pH regulatory enzyme family, carbonicanhydrase (CA, EC 4.2.1.1). KI values of the novel compounds were measured in the range of3.4–73.6 mM for hCA I isozyme and 8.7–1.44.2 mM for hCA II isozyme, respectively. Phenol wasalso tested as standard in order to understand the structure activity relationship and theclinically used sulfonamide acetazolamide was tested for comparison reasons. All of thecompounds exhibited competitive inhibition with 4-nitrophenylacetate as substrate.

ملخص البحث :

Asthma is an inflammatory disease that effect the lung, particularly the airways. So many death cases had been recorded in the last decade due to its complications. As the symptoms (wheezing, SOB, broncho spasm, etc..) frequency per a day increased, the mortality rate increases with the development of bad life style and bad triggers ( smoke, dust, food, car full’s, perfume, medication, food, etc..) there is a serious need to put a focus on the regulation of treatment and life style to these patient. Although asthma is multi factorial ( genetic and environmental predisposing) with no statistically sufficient information in Iraq there is an increase the no hospital admittion daily and delay the responses to the treatment. Aim. to study the biochemical markers effect the cases of asthmas and to evaluate the abnormality in sleeping period, performing the job in these patients and the responses to the medication Methods. A study was made from 200 asthma patient, there were between seventeen and more years old, they admitted to the respiratory center in Najaf province at Sader medical city. It started from 10th of 2018 to 5th of 2019. A data was collected from the patients after direct contact with them or with their relatives. The SPSS version 20 and EXCIL programs were used for analysis of the information . Results. it revealed that the majority of the female patient aged how aged from 40 to 49 years old were depended on inhaled steroid during their first line treatment. These patients suffered from difficulty in having a normal life style or normal job requirement. Most of them suffered from shortness of breath (SOB), wheezing, tightness in the chest, they were suffered from difficulty in normal sleeping. Conclusion: asthma occurrence in Iraq is increased tremendously that required more interest with better improvement of life style to perform a good sleeping period and decrease the hospital admission frequency. Recommendation. a further life style rearrangement and more medical care should be occur to decrease the sudden attacks that it may effect on the life span of the patients.