ملخص البحث :

A novel epidemic infection Coronavirus-19 (COVID-19) considered as one of the challenges in sustainable development. A new-onset of hyperglycaemia has been observed between many COVID-19 patients. The clear explanation of this elevation in fasting plasma glucose (FPG) was debuted. Here we investigate whether this increase is due to impaired insulin secretion or insulin resistance. 269 participants, group 1 (control, n = 46) group 2 (COVID-19 patients, n = 223). 27 Patients were excluded due to missing of their FPG results. FPG, liver enzymes (ALT, AST, and Alk. Phosphatase), b.urea, s.creatinine, s. insulin, C-peptide, D-dimer, and s.ferritin were measured. Our results showed that FPG was increased in 82% (161) patients and this increase was positively correlated with ferritin (r20.039, P-value 0.0013). There is no correlation between FPG with liver enzymes (ALT and AST). The level of insulin hormone and c-peptide were normal. Because there were no increase in insulin or c-peptide and the only relationship was between FPG and ferritin. Therefore, we concluded that COVID-19 infection could cause insulin resistance

ملخص البحث :

Background: The prevalence of pre-diabetes has been increased rapidly not in developing countries only. Pre-diabetes is associated with overweight. The diagnosis criteria of pre-diabetes are controversial issue. Aim of the work: The aim of this study was to establish useful parameters to predict pre-diabetes in overweigh adults. Subject and Methods: Thirty-eight adult participants were enrolled and they were divided into two groups 22 were control healthy volunteers and 16 participants were overweight. Biochemical investigations (glucose level, lipid profile), and High-molecular weight adiponectin (HMW-Adipo) hormone were done for both groups. Results: The results showed that the level of HMW-Adipo was significantly reduced in the overweight group, associated with an increase in fasting plasma glucose (FPG), triglycerides, and reduction in high-density lipoprotein (HDL-C) in the overweight group. The Pearson correlation for Triglyceride glucose- Body Mass Index (TyG-BMI), Body Mass Index (BMI), and tri-Ponderal index were positively correlated with FPG; while HMW-Adipo was negatively correlated with FPG. The area under the curve for TyG-BMI, PI and HMW-Adipo showed an excellent prediction for pre-diabetes in overweight adults. Conclusion: HMW-Adipo and/or TyG-BMI are better predictive markers for pre-diabetes adults rather than TyG-index and impair fasting glucose alone.