ملخص البحث :

Abstract---The study was conducted on 350 aborted women and 30 healthy women who have visited AL-Zahra maternity and paediatrics hospital in AL-Najaf province from November from August to January 2022. This study was designed to determine the effects of T. gondii infection on some parameters such as NLRP3, IL-18, IL-ÃDQGTNF- Â, The results showed a significant elevation (P<0.001) in serum concentration of The current study revealed that serum concentration of NLRP3 (ng/ml), IL-18 (pg/ml), IL-ÃSJPODQG71)-ÂSJPOLQ patients infected with Toxoplasma gondii were significant increase (PO rärrs; (46. 21642 ± 0.524 ng/ml), (474. 12338± 0.906 pg/ml), (15. 41450±0.218 pg/ml), (25.4145065284 ± 0.218232 pg/ml) in compared to the control group (9.701792 ± 0.555 ng/ml), (97.107565 ± 0. 700 pg/ml), (4.129558 ± 0.190 pg/ml), (6.45839 ± 0. 220 pg/ml). The current study has concluded that the infection with T. gondii affects the body's immunity by NLRP3, IL-18, IL-ÃDQGTNF-Â.

ملخص البحث :

Abstract---The study was conducted on 350 aborted women and 30 healthy women who have visited Public Health Laboratory, in Babylon Governorate from August0202 to February 2022. The current study revealed that serum concentration of NF-KB ,IL-18 (pg/ml), IL-2β (pg/ml) and TNF-α (pg/ml) in patients infected with Toxoplasma gondii were significant increase (P< 0.001) (18. 812 ± 0.185 ng/ml), (474. 12338± 0.906 pg/ml), (15. 41450± 0.218 pg/ml), (25. 4145065284± 0.218232 pg/ml) in compared to the control group (8.515 ± 0.515 ng/ml), (97.107565 ± 0. 700 pg/ml), (4.129558 ± 0. 190 pg/ml), (6.45839 ± 0. 220 pg/ml). The current study has concluded that the infection with T. gondii affects the body's immunity by NF-KB, IL-18, IL- 2β and TNF-α. In addition, study was designed to reveal the correlated between NF-KB with IL-18, IL-2β and TNF-α in patients infected with T. gondii. The results of the current study showed the serum concentration of NF-KB was correlated positively and significantly with serum concentration of IL-18, IL-2β and TNF-α.