ملخص البحث :

Renal failure results in the abrupt loss of kidney function, leading to the retention of waste products, electrolyte disturbances, and volume status changes. The estimation of glomerular filtration rate (eGFR) has been recognized as the best standard screening for kidney disease.. the study aimed to estimate the level of HCMV IgM/IgG antibody in renal failure patients and the use of the RFLP-PCR technique in detecting the polymorphism of IL-1B. The study conducted on fifty renal failure patients (34 males and 16 females) and 20 randomly healthy subjects as a control group. The study demonstrated that 22 (44%) of patients’ blood samples were positive for Cytomegalovirus antibody rapid test. plasma concentration IL-1β was estimated in all study groups, the level of IL-1β was significantly elevated in all renal failure patients compared with healthy persons. Digested DNA bands at 190 bp and 115 bp were produced by homozygote genotype of IL-1β-511 (C/C), digested DNA band at 305bp, 190bp, and 115bp were produced by heterozygous genotype of IL-1β-511 (C/T) whereas homozygote genotype of IL-1β-511 (T/T) was produced one fragment 305bp and remained undigested. Conclusion. The renal failure patients are highly susceptible to infection with CMV. CMV IgM/IgG antibody test is an important test in the diagnosis of CMV. The severity of this disease may be associated with the presence of CT genotype and T allele of IL-1β in renal failure patient